pI: 9.0565 |
Length (AA): 1085 |
MW (Da): 126929 |
Paralog Number:
0
Signal peptide: Y | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 10 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
221 | 1008 | 1n0u (A) | 6 | 833 | 14.00 | 0 | 1 | 0.34 | 1.05 |
236 | 407 | 2cxx (A) | 3 | 184 | 20.00 | 0.000000029 | 0.94 | 0.36 | -0.99 |
20 | 172 | 4uos (A) | 24 | 177 | 15.00 | 0.049 | 0.01 | 0.260014 | -0.3 |
230 | 1034 | 2ywe (A) | 2 | 551 | 40.00 | 0 | 1 | 0.425435 | 2.44 |
232 | 1043 | 3cb4 (D) | 2 | 555 | 36.00 | 0 | 1 | 0.450887 | 2.05 |
23 | 163 | 4uos (A) | 27 | 175 | 16.00 | 0.64 | 0.01 | 0.240565 | -0.24 |
230 | 971 | 2ywe (A) | 2 | 551 | 40.00 | 0 | 1 | 0.599027 | 1.74 |
232 | 980 | 3cb4 (D) | 2 | 555 | 36.00 | 0 | 1 | 0.626877 | 1.33 |
234 | 370 | 2dy1 (A) | 9 | 148 | 22.00 | 0.018 | 0.96 | 0.418051 | -0.01 |
235 | 359 | 3vr1 (A) | 13 | 144 | 34.00 | 0.000000000011 | 1 | 0.512309 | -0.13 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | early schizont, early trophozoite, late schizont, late trophozoite, Sporozoite. | PlasmoDB Zanghi G |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | intra-erythrocytic - 16 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, merozoite, Oocyst. | Otto TD PlasmoDB Zanghi G |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | intra-erythrocytic - 0 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, Ring. | Otto TD Zanghi G |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 0-20% percentile | intra-erythrocytic - 8 hs, Female Gametocyte, Male Gametocyte. | Otto TD Lasonder E |
Zanghi G | A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection. |
PlasmoDB | Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB |
Lasonder E | Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression. |
Otto TD | New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq. |
Ortholog group members (OG5_127284)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G39900 | Small GTP-binding protein |
Arabidopsis thaliana | AT5G08650 | small GTP-binding protein |
Babesia bovis | BBOV_III011750 | GTP-binding protein LepA family protein |
Brugia malayi | Bm1_49530 | Hypothetical GTP-binding protein ZK1236.1 in chromosome III |
Candida albicans | CaO19.5483 | similar to E. coli EF-type GTP-binding protein LepA |
Candida albicans | CaO19.12938 | similar to E. coli EF-type GTP-binding protein LepA |
Caenorhabditis elegans | CELE_ZK1236.1 | Protein ZK1236.1 |
Chlamydia trachomatis | CT_064 | elongation factor EF-4 |
Dictyostelium discoideum | DDB_G0291708 | GTP-binding protein |
Drosophila melanogaster | Dmel_CG1410 | waclaw |
Escherichia coli | b2569 | back-translocating elongation factor EF4, GTPase |
Homo sapiens | ENSG00000151806 | GUF1 GTPase homolog (S. cerevisiae) |
Leishmania braziliensis | LbrM.20.0500 | GTP-binding protein, putative |
Leishmania donovani | LdBPK_340590.1 | Translation factor GUF1, mitochondrial, putative |
Leishmania infantum | LinJ.34.0590 | GTP-binding protein, putative |
Leishmania major | LmjF.34.0570 | GTP-binding protein, putative |
Leishmania mexicana | LmxM.33.0570 | GTP-binding protein, putative |
Loa Loa (eye worm) | LOAG_11093 | hypothetical protein |
Mycobacterium leprae | ML0611 | Probable GTP-binding protein LepA |
Mus musculus | ENSMUSG00000029208 | GUF1 GTPase homolog (S. cerevisiae) |
Mycobacterium tuberculosis | Rv2404c | Probable GTP-binding protein LepA (GTP-binding elongation factor) |
Mycobacterium ulcerans | MUL_3667 | GTP-binding protein LepA |
Neospora caninum | NCLIV_060620 | GTP-binding protein LepA, related |
Oryza sativa | 4340102 | Os06g0144800 |
Onchocerca volvulus | OVOC13425 |
|
Plasmodium berghei | PBANKA_0812800 | GTP-binding protein, putative |
Plasmodium falciparum | PF3D7_0911700 | GTP-binding protein, putative |
Plasmodium knowlesi | PKNH_0709700 | GTP-binding protein, putative |
Plasmodium vivax | PVX_099025 | GTP-binding protein, putative |
Plasmodium yoelii | PY03426 | Elongation factor Tu family, putative |
Saccharomyces cerevisiae | YLR289W | GTPase GUF1 |
Trypanosoma brucei gambiense | Tbg972.10.3700 | GTP-binding protein, putative,elongation factor, putative |
Trypanosoma brucei | Tb927.10.2960 | Translation factor GUF1, mitochondrial, putative |
Trypanosoma cruzi | TcCLB.504105.210 | Translation factor GUF1, mitochondrial, putative |
Trypanosoma cruzi | TcCLB.503697.90 | Translation factor GUF1, mitochondrial, putative |
Toxoplasma gondii | TGME49_307980 | GTP-binding protein lepA, putative |
Treponema pallidum | TP0510 | GTP-binding protein LepA |
Theileria parva | TP01_1045 | GTP-binding protein lepA, putative |
Wolbachia endosymbiont of Brugia malayi | Wbm0667 | GTP-binding protein LepA |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.10.2960 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.2960 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.2960 | Trypanosoma brucei | significant gain of fitness in procyclic forms | alsford |
Tb927.10.2960 | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
PBANKA_0812800 | Plasmodium berghei | Slow | plasmo |
TGME49_307980 | Toxoplasma gondii | Probably non-essential | sidik |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.